pUTP Solution GMP-grade (100 mM)
Pseudouridine triphosphate solution for modified RNA synthesis.
Product overview
Natural UTP (uridine triphosphate) consists of uracil, ribose, and triphosphate, while pUTP (pseudouridine-5'-triphosphate) is an isomer of UTP in which uracil is linked to ribose through a C5-C1' carbon-carbon glycosidic bond instead of the N1-C1' bond. Pseudouridine modification can enhance RNA stability and translation efficiency while reducing RNA immunogenicity. It is primarily used in the preparation of modified mRNAs and in nucleic acid drug development. This product is manufactured in accordance with GMP requirements.
Features and applications
- GMP-grade nucleotide solution for RNA synthesis workflows.
- Concentration: 100 mM±3 mM; purity: ≥99% (by HPLC).
- Designed for in vitro transcription of mRNA and related molecular biology applications.
- Nucleotide substrate for in vitro transcription.
- Preparation of modified mRNAs and nucleic acid drug development.
Components
| Item | Specification |
|---|---|
| Molecular Weight | 550.09 |
| CAS | 1175-34-4 (free acid) |
| Molecular Formula | C9H12N2Na3O15P3 |
| Concentration | 100mM±3mM |
| Purity | ≥99%(by HPLC) |
| max λ | 264nm±2nm |
Performance data
1 Purity analysis
Description: Analyze the purity of pUTP solution using HPLC.
Conclusion: Biori provides high-purity pUTP solution.
Shipping and storage
| Condition | Recommendation |
|---|---|
| Storage | Store at -20±5°C. |
| Shipping | Ship frozen on dry ice or with validated frozen cold-chain packaging that maintains the specified frozen storage condition. |
| Handling | Avoid repeated freeze-thaw cycles; mix thoroughly after thawing where applicable. |
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